compusyn calculation software, 2005 edition (ComboSyn Inc)
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Compusyn Calculation Software, 2005 Edition, supplied by ComboSyn Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/compusyn+calculation+software%2C+2005+edition/compusyn+software++2005/pmc08467070-157-4-6
Average 90 stars, based on 1 article reviews
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1) Product Images from "Synergistic Effect of Simultaneous versus Sequential Combined Treatment of Histone Deacetylase Inhibitor Valproic Acid with Etoposide on Melanoma Cells"
Article Title: Synergistic Effect of Simultaneous versus Sequential Combined Treatment of Histone Deacetylase Inhibitor Valproic Acid with Etoposide on Melanoma Cells
Journal: International Journal of Molecular Sciences
doi: 10.3390/ijms221810029
Figure Legend Snippet: Fa-CI plot analysis of the synergistic and antagonistic effects of different VPA and ETO treatment schemes on inhibiting melanoma cells. The combination index (CI) values for simultaneous versus sequential combined treatments of VPA and ETO treatment schemes on ( a ) B16-F10 and ( b ) SK-MEL-2-Luc cells were calculated based on Chou and Talalay’s method via CompuSyn analysis software, 2005 Edition (ComboSyn, Paramus, NJ, USA). This analysis evaluates the effectiveness of combination treatment under the specified order of drug administration. In the Fa-CI plot, fractions of affected cells (Fa) represent the dead cells after drug treatments. Circle, square, and triangle symbols represent the CI values of each Fa under the specified treatment scheme with different orders of drug administration. The range of Fa is from 0 (no inhibition) to 1 (complete inhibition). The CI values are quantitative grading of synergism (CI < 1), additive (CI = 1), and antagonism (CI > 1). The IC 12.5 , IC 25, and IC 50 values are listed in . IC 50 values are summarized in .
Techniques Used: Software, Inhibition
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